The 25-year-old scored as Arsenal secured an impressive 2-0 victory over their bitter rivals on Saturday launch-time.
The Germany international opened the scoring with a fantastic header in the first-half before Chile international Alexis Sanchez made it 2-0 for Arsenal before the break.
The Gunners showed a dominant performance and Tottenham failed to create too many clear cut chances throughout the 90 minutes.
Arsenal supporters were quick to take to social media to praise the defender for his overall performance against their bitter rivals.
Football Weeks has rounded up some of the best tweets:
Mustafi absolutely bossing this game!
— Joshua Smith AFC?⚪️ (@smithyboy2015) November 18, 2017
Mustafi 10/10 performance
— . (@Hrishi_AFC) November 18, 2017
Mustafi world class
— D (@afc_ramble) November 18, 2017
Mustafi is motm so far
— Ahmed (@MadoAfc) November 18, 2017
Mustafi you hero
— Luk3 #Arsenal (@__Luk3) November 18, 2017
Arsenal on Saturday now find them one point behind Tottenham in the Premier League table following a mixed start to the season.
Mustafi has endured a tough start to the early stages of the season after he suffered a hamstring injury, which has ruled him out of the club last four Premier League matches.
Arsenal will look to build on this result when they face FC Cologne in the Europa League on Thursday night.